Martin Dawes

Biography

Diabetes: In 2012/2013 I ran a CIHR funded pilot cluster randomised controlled trial to examine feasibility of diabetes prevention program using family physician lifestyle prescription facilitation.

Hypertension: Starting in 1994 I ran a 10,000-patient cohort study evaluating the role of ambulatory blood pressure monitoring and white coat hypertension in predicting mortality. I helped run other interventional studies focusing on accurate measurement of BP. I was chair of the hypertension guideline group in BC in 2020. We have just completed a survey of BP measurement during the Covid epidemic.

Evidence Based Medicine: 1994 – The setting up and running of the Masters of Evidence-Based Health Care at Oxford University with its international and national multi professional characteristics was a unique development setting a pattern for other courses. I edited a textbook on evidence-based practice followed by a 2nd edition.

Pharmacogenetics in Primary Care

At McGill in 2008, I ran a study on pharmacogenetics for warfarin in primary care. At UBC I led a team to investigate the implementation of pharmacogenetics in primary care. We set up a lab with a Quant Studio qPCR to develop a primary care pharmacogenetic assay. This work tested the software and genetic tests establishing the feasibility of implementing pharmacogenetics into primary care.

Medication Decision Support

For translation of pharmacogenetics data in practice I set up and led an interdisciplinary team of pharmacists, epidemiologists, and doctors at UBC. It has developed a software program to translate these test results into a list of safe effective drug options, tailored to each individual patient. A spin out company, GenXys Health Care Systems was formed, and I am CSO of that company.

To learn more about Dr. Dawes research and projects, please visit: LinkedIn or ResearchGate.

Publications in Last Five Years:

1.Dix-Cooper, L., Dawes, M. & Park, M. Vancouver Coastal Health informed COVID-19 response by applying rapid review methodology: Reply to Tricco. J Clin Epidemiol (2021) doi:10.1016/j.jclinepi.2021.02.027.

2.Dawes, M. et al. The challenges of measuring blood pressure during COVID-19: How to integrate and support home blood pressure measurements. Can Fam Physician 67, 112–113 (2021).

3.Rafi, I. et al. The implementation of pharmacogenomics into UK general practice: a qualitative study exploring barriers, challenges and opportunities. J Community Genetics 1–9 (2020) doi:10.1007/s12687-020-00468-2.

4.Dawes, D. et al. Development of five online modules for teaching evidence-informed healthcare: the West coast Interprofessional Clinical Knowledge Evidence Disseminator (WICKED) Project. BMJ Evidence-based Medicine bmjebm-2020-111399 (2020) doi:10.1136/bmjebm-2020-111399.

5.Dawes, M., Katzov-Eckert, H., Paterson, A. & Dawes, D. Re: Pharmacogenetic Testing Options Relevant to Psychiatry in Canada. Can J Psychiatry 65, 584–585 (2020).

6.Rafi, I., Hayward, J. & Dawes, M. Pharmacogenomics: Prescribing based on genetic variation. Innovait Educ Inspiration Gen Pract 175573802097212 (2020) doi:10.1177/1755738020972128.

7.Dawes, M. Pharmacogenetics in primary care. Health Management Forum 084047041990128 (2020) doi:10.1177/0840470419901285.

8.Greiver, M. et al. Trends in end digit preference for blood pressure and associations with cardiovascular outcomes in Canadian and UK primary care: a retrospective observational study. BMJ Open 9, e024970 (2019).

9.Zusman, E. Z. et al. Older Adults’ Sedentary Behavior and Physical Activity After Hip Fracture. J Geriatr Phys Ther, NA; (2018).

10.Bartlett, G. et al. The Importance of Relevance: Willingness to Share eHealth Data for Family Medicine Research. Frontiers Public Heal 6, 255 (2018).

11.Tseng, O. L. et al. Aromatase inhibitors are associated with a higher fracture risk than tamoxifen: a systematic review and meta-analysis. Ther Adv Musculoskelet Dis 10, 71 90 (2018).

12.Nolan, R. P. et al. Randomized Controlled Trial of E-Counseling for Hypertension. Circulation Cardiovasc Qual Outcomes 11, e004420 (2018).

13.Tseng, O. L. et al. Promoting bone health management in women diagnosed with breast cancer: a pilot randomized controlled trial. Arch Osteoporos 13, 52 (2018).

14.Ang, J. S. et al. Evaluation of buccal swabs for pharmacogenetics. BMC Res Notes 11, 382 (2018).

15.Bartlett, G., Dawes, M., Nguyen, Q. & Phillips, M. S. Chapter 5 Precision Medicine in Primary Health Care. 101 113 (2017). doi:10.1016/b978-0-12-809411-2.00005-2.

16.Dawes, M. How can the “omics” revolution change primary care. Fam Pract 34, 125 126 (2017).

17.Kaczorowski, J. et al. How do family physicians measure blood pressure in routine clinical practice?: National survey of Canadian family physicians. Canadian Family Physician 63, 193 199 (2017).

18.Tseng, O. L., Spinelli, J. J., Dawes, M. & McBride, M. L. Cervical cancer screening for survivors diagnosed with cancer before age 25. J Cancer Surviv 11, 410–419 (2017).

19.Housden, L., Browne, A. J., Wong, S. T. & Dawes, M. Attending to power differentials: How NP-led group medical visits can influence the management of chronic conditions. Health Expect 20, 862 870 (2017).

20.Tseng, O. L., Dawes, M. G., Spinelli, J. J., Gotay, C. C. & McBride, M. L. Utilization of bone mineral density testing among breast cancer survivors in British Columbia, Canada. Osteoporosis Int 28, 3439–3449 (2017).

21.McEwen, L. M. et al. DNA methylation signatures in peripheral blood mononuclear cells from a lifestyle intervention for women at midlife: A pilot RCT. Appl Physiology Nutrition Metabolism 10, 4 (2017).

22.Anderson, T. J. et al. 2016 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in the Adult. Can J Cardiol 32, 1263 1282 (2016).

23.Housden, L., Wong, S. T., Browne, A. J. & Dawes, M. Complexities of Introducing Group Medical Visits With Nurse Practitioners in British Columbia. Policy Politics Nurs Pract 17, 198–207 (2016).

24.Dawes, M. et al. Introducing pharmacogenetic testing with clinical decision support into primary care: a feasibility study. CMAJ Open 4, E528–E534 (2016).

 

Contact:
320-5950 University Boulevard, Department of Family Practice, UBC
Vancouver, BC V6T 1Z3 Canada
martin.dawes@ubc.ca